Pregnancy rates of Crete Fertility Centre –performing it: ~48 – 50% ICSI, is a micromanipulation technique developed to help achieve fertilization for couples with severe male factor infertility or couples who have had failure to fertilize in a previous IVF attempt. The technique involves: picking up a single live sperm injecting it directly into the center of a human egg. Pregnancy rates are comparable to those seen with IVF in couples with no male factor infertility.